— First of Two Unique ImmunoGen Product Candidates Expected to
Today
"The Phase I trial now underway, together with our market research, is expected to provide the information needed to define a clear development path for IMGN529 in NHL," commented James O'Leary, MD, Vice President and Chief Medical Officer. "With its unique profile, we believe IMGN529 has the potential to be an important new therapy for the treatment of key B-cell malignancies."
About the Phase I Trial Initiated
This multi-center, first-in-human Phase I trial is expected to enroll approximately 55 patients with relapsed or relapsed/refractory, CD37-expressing
About IMGN529
ImmunoGen created IMGN529 for the treatment of B-cell malignancies that express its CD37 target. The prevalence of CD37 on malignant cells is similar to that of CD20, the target for rituximab: it is expressed widely on key
IMGN529 contains a CD37-targeting ImmunoGen antibody that, in vitro, has been found to kill cancer cells through multiple mechanisms of action including pro-apoptotic activity, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).1,2 The attached DM1 kills cancer cells through a different mechanism — disruption of a key step that occurs during cell division.
About Non-Hodgkin's lymphoma
About
1Mayo M. et al., AACR 2011, abstract #4581.
2Deckert J. et al., AACR 2011, abstract #4565.
3
Rituxan® is a registered trademark of Biogen Idec Inc.
This press release includes forward-looking statements. For these statements, ImmunoGen claims the protection of the safe harbor for forward-looking statements provided by the Private Securities Litigation Reform Act of 1995. It should be noted that there are risks and uncertainties related to the development of novel anticancer products, including IMGN529, including risks related to preclinical and clinical studies, their timings and results. A review of these risks can be found in ImmunoGen's Annual Report on Form 10-K for the fiscal year ended
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