AbbVie Initiates Phase 2 Clinical Trial Programs for ABBV-8E12, an Investigational Anti-Tau Antibody, in Early Alzheimer's Disease and Progressive Supranuclear Palsy

NORTH CHICAGO, Ill., Jan. 25, 2017 /PRNewswire/ -- AbbVie (NYSE: ABBV), a global biopharmaceutical company, announced the start of two Phase 2 clinical trial programs to evaluate ABBV-8E12, an investigational anti-tau antibody, in patients with early Alzheimer's disease and progressive supranuclear palsy (PSP). In recognition of the lack of treatment options available to patients with PSP, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to ABBV-8E12. The FDA and European Medicines Agency (EMA) also granted Orphan Drug Designations to ABBV-8E12 for PSP.1,2

Jan 10, 2017

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New Data Presented At ECTRIMS Reinforce Efficacy of ZINBRYTA™ (daclizumab) and Support Long-Term Safety Profile

Cambridge, Mass. & North Chicago, Ill. – September 15, 2016 – A new post-hoc analysis from the pivotal DECIDE study shows that a significantly greater number of people treated with ZINBRYTATM (daclizumab) achieved no evidence of disease activity (NEDA) compared to those taking AVONEX® (interferon beta-1a) intramuscular injection. The findings continue to support the positive impact of ZINBRYTA on NEDA status. Additional new interim data from the long-term extension study, EXTEND, further affirm ZINBRYTA’s efficacy on clinically meaningful measures of multiple sclerosis (MS) disease activity and provide additional information supporting ZINBRYTA’s safety profile. These results were presented by Biogen (NASDAQ: BIIB) and AbbVie (NYSE: ABBV) at the 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in London.
 

How to Overcome the Blood-Brain Barrier to Deliver New Medicines

The brain’s protection barrier prevents medicines from getting in, but new approaches are finding ways to bust through and treat central nervous system diseases.

Biogen And AbbVie’s Once-Monthly ZINBRYTA™ (daclizumab) Approved In European Union For Treatment Of Multiple Sclerosis

Cambridge, Mass. & North Chicago, Ill. – July 5, 2016 – The European Commission (EC) has granted marketing authorization for ZINBRYTA™ (daclizumab) for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS), Biogen (NASDAQ: BIIB) and AbbVie (NYSE: ABBV) announced today. ZINBRYTA is a once-monthly, self-administered, subcutaneous injection.
 

Biogen and AbbVie Receive FDA Approval of Once-Monthly ZINBRYTA™ (daclizumab) for Multiple Sclerosis

CAMBRIDGE, Mass. and NORTH CHICAGO, Ill., May 27, 2016 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) approved ZINBRYTA™ (daclizumab), a new once-monthly, self-administered, subcutaneous treatment for relapsing forms of multiple sclerosis (RMS), Biogen (NASDAQ: BIIB) and AbbVie (NYSE: ABBV) announced today. Because of its safety profile, the use of ZINBRYTA should generally be reserved for patients who have had an inadequate response to two or more therapies indicated for the treatment of multiple sclerosis (MS). 

Combing Through the Tangles of Alzheimer’s

Researchers are homing in on the tau protein as a likely culprit in the development of Alzheimer’s disease.

Our Foundational Neuroscience Center Opens in Cambridge, Massachusetts

A 43,000-square-foot research center in the Cambridge, Massachusetts, biotech corridor will be devoted to neurodegenerative diseases such as Alzheimer’s.
 

Biogen and Abbvie Receive Positive Opinion From The CHMP on ZINBRYTA™ (daclizumab) For Treatment Of Multiple Sclerosis

Cambridge, Mass. & North Chicago, Ill. –April 29, 2016 The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the granting of a marketing authorization for ZINBRYTA™ (daclizumab) intended for the treatment of relapsing forms of multiple sclerosis (RMS), Biogen (NASDAQ: BIIB) and AbbVie (NYSE: ABBV) announced today. ZINBRYTA is a once-monthly, self-administered, subcutaneous investigational treatment for RMS. ZINBRYTA is also currently under regulatory review in the United States, Switzerland, Canada and Australia.
 

Data Presented At AAN Highlight Impact Of ZINBRYTA™ (daclizumab HYP) On Cognitive Outcomes And The Reversibility Of Its Targeted Mechanism Of Action

Cambridge, Mass. & North Chicago, Ill. – April 20, 2016 New data presented today show that investigational therapy ZINBRYTATM (daclizumab HYP) provided improvements on cognitive outcome measures in people living with relapsing forms of multiple sclerosis (RMS). Additional data offer insight into ZINBRYTA’s targeted mechanism of action (MOA), demonstrating that it did not cause broad immune cell depletion and its effects on total lymphocyte counts were reversible within approximately 8 to 12 weeks upon treatment discontinuation. These results were presented by Biogen (NASDAQ: BIIB) and AbbVie (NYSE: ABBV) at the 68th annual meeting of the American Academy of Neurology (AAN) in Vancouver, Canada.